Cadmium Induced Oxdative Stress in Heptaocytes of Snakehead Fish Channa Punctatus (bloch.)- a Invitro Study

Present study has been undertaken to assess the toxicity of cadmium in vitro for viability of hepatocytes, lactate dehydrogenase leakage, glutathione and lipid peroxidation in Channa punctatus (Bloch), a freshwater snake head fish. Three concentrations of cadmium as cadmium chloride (0.1μg/ml; 3.0μg/ml and 5.0μg/ml) besides one control has been selected. Observations reveal that except lowest concentration of cadmium (0.10μg/l), the rest two concentration (3.0μg/ml and 5. 0μg/ml) exerted significant decline (P<0.05) in the viability of heptocytes, lactic dehydrogenase leakage and glutathione as compared to control. However, significant increase (P<0.05) was noticed in the lipid peroxidation in terms of MDA (Malon-di aldehyde) treated with 3.0μg/ml and 5.0μg/ml of cadmium chloride concentration as compared to control. Lowest concentration (1. 0μg/ml) of cadmium chloride could produce no significant alteration in lipid per oxidation. Causo-mechanism of these findings has been discussed in this